chipset is commonly used to refer to a set of specialized chips on a computer's motherboard or an expansion card. In personal computers based on Intel Pentium-class microprocessors, the term often refers to a specific pair of chips on the motherboard: the northbridge and the southbridge. The northbridge links the CPU to very high-speed devices, especially main memory and graphics controllers, and the southbridge connects to lower-speed peripheral buses (such as PCI or ISA). In many modern chipsets, the southbridge actually contains some on-chip integrated peripherals, such as Ethernet, USB, and audio devices. A chipset is usually designed to work with a specific family of microprocessors. Because it controls communications between the processor and external devices, the chipset plays a crucial role in determining system performance.

The manufacturer of a chipset often is independent from the manufacturer of the motherboard. Current manufacturers of chipsets for PC-compatible motherboards include NVIDIA, AMD, VIA Technologies, SiS, Intel and Broadcom. Apple computers and Unix workstations from Sun, NeXT, SGI, and others have traditionally used custom-designed chipsets; now that Sun and Apple have adopted x86 processors, they have begun to use standard PC chipsets in some of their computers. Some server manufacturers also develop custom chipsets for their products.

In the 1980s, Chips and Technologies, founded by Dado Banatao (who later founded S3 Graphics), pioneered the manufacturing of chipsets for PC-compatible computers. Computer systems produced since then often share commonly used chipsets, even across widely disparate computing specialties. For example, the NCR 53C9x, a low-cost chipset implementing a SCSI interface to storage devices, could be found in Unix machines such as the MIPS Magnum, embedded devices, and personal computers.

In home computers, game consoles and arcade game hardware of the 1980s and 1990s, the term chipset was used for the custom audio and graphics chips. Examples include the Commodore Amiga's Original Chip Set or SEGA's System 16 chipset.