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Tobey Maguire …. Peter Parker/Spider-Man
Kirsten Dunst …. Mary Jane Watson
Thomas Haden Church …. Sandman
James Franco …. Harry Osborn
Topher Grace …. Venom
rest of cast listed alphabetically:
Terrell Anthony …. Lab Tech #6
Dylan Baker …. Dr. Curt Connors
Elizabeth Banks …. Betty Brant
Christina Cindrich …. Lab Technician
Paul Terrell Clayton …. Technician
Carolyn Neff …. Lab Tech #3
Edward Padilla …. Lab Tech #5