Homme's traditional setup has been Ovation Ultra GP guitars (3 different finishes, though the wine red one is rarely seen) played through a collection of Ampeg Vt-22 combos. The Ovation guitars were part of a limited production run, with less than 1000 made in 1984. Homme is evasive about his guitar equipment, choosing to either change the subject or even lie when asked about his setup in interviews. However it has been established that Homme owns three 1984 Ovation GPs (one sunburst, one black, and one red),[12] and that he often downtunes his guitar to C standard.

For the “Blues for the Red Sun” tour with Kyuss in 1993, Homme used a cream colored Gibson Les Paul and a SG. This guitar was also used during Homme's tour with the Screaming Trees after Kyuss' break-up.[citation needed]